Handbook Of Antithrombotic Therapy

The fourth edition of this handbook is designed to give the practitioner convenient access to practical information on established and emerging antithrombotic agents. Proper use of these agents can substantially reduce mortality and morbidity in patients with thrombotic diseases.
Whenever possible, algorithms are used to aid in dosing and monitoring antithrombotic agents. Some of these algorithms have been validated in prospective studies (pages 8 and 9) whereas others (pages 30-37) are derived from widespread experience. The reader should keep in mind that these algorithms are recommendations and not rigid practice guidelines. The reader will also find flow charts to help in the diagnostic approach to important thrombotic diseases including pulmonary embolism (PE), deep venous thrombosis (DVT), atrial fibrillation (AF), and myocardial infarction (MI).
Table Of Contents
Heparin
Introduction
Indications and Precautions
Dosing and Therapeutic Ranges
Guidelines for Overlapping Heparin and Warfarin
Monitoring and Dose Adjustment
Weight-Based Monitoring and Dose Adjustment
Prevention of Deep Venous Thrombosis/Pulmonary Embolism
Bleeding in Patients Receiving Heparin.
Determining the Therapeutic Range of Heparin
Evaluation of Patients with Suspected Deep Venous Thrombosis
Evaluation of Patients with Suspected Pulmonary Embolism
Low Molecular Weight Heparins and Danaparoid
Introduction
Indications and Dosing
Warfarin
Introduction
Indications and Precautions
Drug Interactions with Warfarin
INR Considerations
Initiating Warfarin Therapy
Monitoring and Dose Adjustments
Managing Warfarin in Patients Undergoing Surgery
Bleeding in Patients on Warfarin
Prevention of Deep Venous Thrombosis/Pulmonary Embolism
Evaluation of Patients with Atrial Fibrillation
Aspirin
Introduction
Dose Regimens
Indications and Precautions
Clopidogrel
Introduction
Indications and Precautions
Ticlopidine
Introduction
Indications and Precautions
Aspirin - Extended Release Dipyridamole
Platelet Glycoprotein IIb/IIIa Inhibitors
Abciximab
Eptifibatide
Tirofiban
Thrombolytic Agents
Introduction
Indications and Precautions
Dosing in Myocardial Infarction
Rapid Evaluation of Patients with Acute Myocardial Infarction.
Dosing tPA (alteplase) in Acute Ischemic Stroke
Dosing in Pulmonary Embolism/Deep Venous Thrombosis
Managing Heparin and Thrombolytic Therapy
Other Regimens
Lepirudin and Argatroban in Acute Heparin Induced Thrombocytopenia
Antithrombotic Therapy During Pregnancy
Additional Reading
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